Paul Heppenstall

Selected Journal Articles

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  23/1/2024 Cellular and Molecular Life Sciences

  Ribosomal protein L24 mediates mammalian microRNA processing in an evolutionarily conserved manner

  Yonat Tzur, Serafima Dubnov, Nimrod Madrer, Adi Bar, Bettina Nadorp, Nibha Mishra, Paul Heppenstall, Estelle R. Bennett, David S. Greenberg, Katarzyna Winek, Hermona Soreq
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  Cell Rep. 2022 Jan 18;38(3):110260. doi: 10.1016/j.celrep.2021.110260. PMID: 35045284.

  TrkC-CreERT2-mediated recombination supports evidence that TrkC+/TH+ DRG neurons contribute to cardiovascular homeostasis.

  Heppenstall PA, Castaldi L, Morelli C.
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  Pain. 2021 May 1;162(5):1334-1351. doi: 10.1097/j.pain.0000000000002159. PMID: 33492037.

  A genome-wide screen reveals microRNAs in peripheral sensory neurons driving painful diabetic neuropathy.

  Bali KK, Gandla J, Rangel DR, Castaldi L, Mouritzen P, Agarwal N, Schmelz M, Heppenstall P, Kuner R.
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  Cell Rep. 2021 Jun 1;35(9):109191. doi: 10.1016/j.celrep.2021.109191. PMID: 34077727; PMCID: PMC8187988.

  Identification of a population of peripheral sensory neurons that regulates blood pressure.

  Morelli C, Castaldi L, Brown SJ, Streich LL, Websdale A, Taberner FJ, Cerreti B, Barenghi A, Blum KM, Sawitzke J, Frank T, Steffens LK, Doleschall B, Serrao J, Ferrarini D, Lechner SG, Prevedel R, Heppenstall PA.
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  Arthritis Rheumatol. 2020 Oct;72(10):1749-1758. doi: 10.1002/art.41314. Epub 2020 Aug 11. PMID: 32418284.

  Intraarticular Adeno-Associated Virus Serotype AAV-PHP.S-Mediated Chemogenetic Targeting of Knee-Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice.

  Chakrabarti S, Pattison LA, Doleschall B, Rickman RH, Blake H, Callejo G, Heppenstall PA, Smith ESJ.
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  Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14260-14269.

  Structure-guided examination of the mechanogating mechanism of PIEZO2

  Taberner FJ, Prato V, Schaefer I, Schrenk-Siemens K, Heppenstall PA, Lechner SG.
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  Pain. 2019 Oct;160(10):2305-2315.

  Nerve growth factor-mediated photoablation of nociceptors reduces pain behavior in mice

  Nocchi L, Portulano C, Franciosa F, Doleschall B, Panea M, Roy N, Maffei M, Gargano A, Perlas E, Heppenstall PA.
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  Nat Protoc. 2019 Nov;14(11):3101-3125.

  One-step site-specific antibody fragment auto-conjugation using SNAP-tag technology

  Hussain AF, Heppenstall PA, Kampmeier F, Meinhold-Heerlein I, Barth S.
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  Journal of Neuroscience

  The NGFR100W Mutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V

  Giovanna Testa, Marco Mainardi, Chiara Morelli, Francesco Olimpico, Laura Pancrazi, Carla Petrella, Cinzia Severini, Rita Florio, Francesca Malerba, Antonia Stefanov, Enrica Strettoi, Rossella Brandi, Ivan Arisi, Paul Heppenstall, Mario Costa, Simona Capsoni and Antonino Cattaneo.

   
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  Sci Rep.

  A ligand-based system for receptor-specific delivery of proteins

  Maffei M, Morelli C, Graham E, Patriarca S, Donzelli L, Doleschall B, de Castro Reis F, Nocchi L, Chadick CH, Reymond L, Corrêa IR Jr, Johnsson K, Hackett JA, Heppenstall PA.
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  2019, Angew Chem Int Ed Engl. 18;58(8):2341-2344.

  A Chemogenetic Approach for the Optical Monitoring of Voltage in Neurons

  Sundukova M, Prifti E, Bucci A, Kirillova K, Serrao J, Reymond L, Umebayashi M, Hovius R, Riezman H, Johnsson K, Heppenstall PA.  
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  2019, Nat Biomed Eng. 3(2):114-125.

  Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice

  Nocchi L, Roy N, D'Attilia M, Dhandapani R, Maffei M, Traista A, Castaldi L, Perlas E, Chadick CH, Heppenstall PA. 
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  2018, Nat Commun. 24;9(1):1640.

  Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

  Dhandapani R, Arokiaraj CM, Taberner FJ, Pacifico P, Raja S, Nocchi L, Portulano C, Franciosa F, Maffei M, Hussain AF, de Castro Reis F, Reymond L, Perlas E, Garcovich S, Barth S, Johnsson K, Lechner SG, Heppenstall PA.  
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  Neuron 93(1):179-193.

  Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination

  Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA, Lechner SG. 
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  Sci Rep 7(1)

  ATP release during cell swelling activates a Ca(2+)-dependent Cl(-) current by autocrine mechanism in mouse hippocampal microglia

  Murana E, Pagani F, Basilico B, Sundukova M, Batti L, Di Angelantonio S, Cortese B, Grimaldi A, Francioso A, Heppenstall P, Bregestovski P, Limatola C, Ragozzino D.

   
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  Nat Commun 8(1):1778.

  Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

  Simeoli R, Montague K, Jones HR, Castaldi L, Chambers D, Kelleher JH, Vacca V, Pitcher T, Grist J, Al-Ahdal H, Wong LF, Perretti M, Lai J, Mouritzen P, Heppenstall P, Malcangio M. 

   
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  Cell Rep 21(11):3102-3115.

  Functional and Molecular Characterization of Mechanoinsensitive "Silent" Nociceptors

  Prato V, Taberner FJ, Hockley JRF, Callejo G, Arcourt A, Tazir B, Hammer L, Schad P, Heppenstall PA, Smith ES, Lechner SG. 

   
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  Science 353(6306):1393-1398.

  The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia

  Song K, Wang H, Kamm GB, Pohle J, Reis FD, Heppenstall P, Wende H, Siemens J.
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  ELIFE 5 doi: 10.7554/eLife.20813

  Acetylated tubulin is essential for touch sensation in mice

  Morley SJ, Qi YM, Iovino L, Andolfi L, Guo D, Kalebic N, Castaldi L, Tischer C, Portulano C, Bolasco G, Shirlekar K, Fusco CM, Asaro A, Fermani F, Sundukova M, Matti U, Reymond L, De Ninno A, Businaro L, Johnsson K, Lazzarino M, Ries J, Schwab Y, Hu J, Heppenstall PA.