Ion channels in health and disease

Ion channels are key molecules for signal transduction across biological membranes. This research area explores the role of ion channels in health and neurodegenerative diseases.

Calcium-activated chloride channels

We use the patch-clamp technique combined with site-specific mutagenesis, immunohistochemistry and computational studies to understand the physiological role of these channels in sensory systems.(Anna Menini's lab)»


Properties of cyclic nucleotide gated ionic channels

We are using site specific mutagenesis combined with patch clamp electrical recordings to characterize electrical properties of cyclic nucleotide gated channels (Vincent Torre's lab)  »


Integration of signals at the level of single neurons

Patch clamp, intracellular and extracellular recording techniques are employed to understand the basic mechanisms of repeated electrical oscillations produced by brain neurons in health and neurodegenerative disease models (Andrea Nistri's lab)»


Modulation of neurotransmitter receptors related to pain mechanisms

This project addresses the issue of how intracellularly synthetized and released factors can modulate the efficiency of signal transmission in the CNS, facilitating or depressing the propagation of weak or strong signals, respectively (Andrea Nistri's lab)»


Molecular neuroscience of motoneuron disease: insights into pathology and protection mechanisms

We study the potential involvement in motoneuron progressive degeneration of microglia-synaptic cross-talk (Laura Ballerini's lab)»


Biology of Pain

Our work aims to delineate the biochemical pathways downstream of ATP sensing in neuronal and glial cell models, with a special emphasis on validation of new interfering methods using the last generation of drug-targeting approaches.»


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