Galvanetto 2018

2018 - Biophys J. 2018 Mar 27;114(6):1264-1266. doi: 10.1016/j.bpj.2018.02.004

Fodis: Software for Protein Unfolding Analysis

Galvanetto N, Perissinotto A, Pedroni A, Torre V


The folding dynamics of proteins at the single-molecule level has been studied with single-molecule force spectroscopy experiments for 20 years, but a common standardized method for the analysis of the collected data and for sharing among the scientific community members is still not available. We have developed a new open-source tool-Fodis-for the analysis of the force-distance curves obtained in single-molecule force spectroscopy experiments, providing almost automatic processing, analysis, and classification of the obtained data. Our method provides also a classification of the possible unfolding pathways and the structural heterogeneity present during the unfolding of proteins.


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