Deumens 2013

2013 - Neuroscience 2013,229:155-63.

Early hyperexcitability of distal dorsal horn networks after experimental focal lesion of the rat spinal cord in vitro.

Deumens R, Mazzone GL, Taccola G.

Abstract:

Hyperexcitability of dorsal horn neurons has been shown to play a key role in neuropathic pain following chronic experimental spinal cord injury. With a neonatal in vitro spinal cord injury model, we show that a chemically-induced lesion leads to rapid gain-of-function of sublesional dorsal horn networks biased to hyperexcitation. The expression of the GABA synthetic enzyme GAD65 was significantly reduced at the same level of the spinal cord, suggesting a compromised inhibitory system. We propose that our model could be useful to test early approaches to contrast spinal cord injury-induced central sensitization of dorsal horn circuits.

 

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