Projects

current projects

ByAxon - Towards an active bypass for neural reconnection

 ByAxon
ByAxon is devoted to the development of a new generation of sensors and electrodes based on nanotechnology materials for neural interfacing.
 

GRAPHENE Core 1

This proposed flagship aims to take graphene and related layered materials from a state of raw potential to a point where they can revolutionize multiple industries – from flexible, wearable and transparent electronics, to high performance computing and spintronics. We will do so by bringing together a large European consortium of world-leading academics and key industries, working closely to create a new disruptive technology.
 

Neuroscaffolds - Rapid prototyping scaffolds for the nervous system

Neuroscaffolds
Advanced tissue engineering requires scaffolds fabricated at different scales to facilitate cellular repair. Neurons respond to micro and nanopatterns over which are grown and it is possible to control - to some extent – neurite protrusion and the formation of neuronal network by using only nanopatterns.
 

Focus - Single Molecule Activation and Computing

Focus
The main objective of this project was the development of new MDs. This major objective was based on the realization of supporting technological advancements and computational progress. It was based also on suggestions obtained from a biological analysis.
 

Application of Advanced Nanotechnology in the Development of Innovative Cancer Diagnostics Tools

The proposal aims at generating an innovative nanotechnology-based intrinsically high throughput platform to carry out real-time, highly sensitive, and inexpensive quantification of biomarkers for cancer risk assessment.
 

Nanotechnological approaches toward tumor theragnostic

The project is focused on the development of innovative devices and therapeutic protocols based on the nanomechanical response of biomolecular nanostructures.
 

Neuroscience of Knowledge - Neural representations of concepts and their role in perception and memory

Mathew Diamond and Davide Zoccolan, two neuroscientists of the International School for Advanced Studies (SISSA) of Trieste, are among the recipients of an important award that will Finance an international research project over the next three years.
 

CARBONANOBRIDGE - Neuron networking with nano bridges via the synthesis and integration of functionalized carbon nanotubes

We propose the development of novel nanodevices, such as nanoscale bridges and nanovectors, based on functionalized carbon nanotubes (CNT) for manipulating neurons and neuronal network activity in vitro. The main aim is to put forward innovative solutions that have the potential to circumvent the problems currently faced by spinal cord lesions or by neurodegenerative diseases.
 

Mechanisms underlying altered GABAergic signaling in the hippocampus of transgenic mice carrying the human R451C mutation of the NLG3 gene: an animal model of autism

Autism Spectrum Disorders (ASD) comprise a heterogeneous group of neuro-developmental disorders, mainly of genetic origin, characterized by impaired social interactions, communications deficits and stereotyped behaviors.
 

Integrated analysis of molecular and cellular mechanisms underlying signal processing by sensory systems in health and disease

Sensory systems allow all organisms to receive information from the external world and play an essential role in species survival and reproduction, as well as in well-being. It is therefore very important to be able to treat diseases that affect sensory signaling, such those associated with disorders in vision, balance, hearing, taste and smell. This goal requires a precise understanding of how sensory signaling occurs at a molecular and cellular level both in health and in disease conditions.
 

In Vitro locomotor patterns - Innovative protocols of electrical stimulation to activate the in vitro locomotor pattern

In these last years, growing attention has been drawn upon the use of epidural electrical stimulation applied to the dorsal spinal cord to counteract a wide range of neurological disturbances. Among the different therapeutical purposes, should be mentioned the recovery of standing posture and locomotion after a spinal cord injury. Currently, these applications exploit the same stimulating protocol that has been used for decades, which is composed of a train of stereotyped impulses, square or sinusoidal, with frequencies that vary within a limited range.
 

Trigeminal pain and migraine - Molecular mechanisms of trigeminal pain with particular emphasis on migraine

This project combines molecular biology, confocal microscopy, cell biology and electrophysiology to understand the process of pain transduction by trigeminal sensory neurons.
 

Neurodegeneration in motor disorders - Molecular mechanisms of neurodegeneration in motor disorders

This project is focused on the mechanisms of early processes of cell death in experimental models of spinal cord injury and amyotrophic lateral sclerosis (ALS).
 

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