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Elsa Fabbretti

 
Biology of pain

Elsa FabbrettiAssociate Professor, University of Nova Gorica
 

Elsa Fabbretti is Associate Professor in Molecular and Cell Biology, University of Nova Gorica, Slovenia, and external collaborator at SISSA in Neuroscience Area.

She got her Biology Degree in 1993, at the University of Trieste, Italy. In 2001 she obtained her PhD in Molecular Genetics at SISSA.

From 2002 to 2009, Elsa Fabbretti was post-doc researcher at SISSA in the Neurobiology Sector. In 2006 she was in Paris as a short-term visiting scientist, at the Institute Curie, INSERM Unit 653 (Immunity and cancer).

She is author of 31 peer-review scientific articles, with 695 citations and h-index 13 (2012). She was also awarded from Slovenian Science Foundation, for the best dissemination event (2011).

 

Research Lines

Biology of Pain 

One of my main interests is the study of integrated tissue responses in chronic pain conditions and peripheral neuronal hypersentisation, especially focused on ATP signaling. The main question is how to identify key molecular switches responsible for irreversible transitions of sensory ganglia from a healthy basal state to a diseased one. One emerging hypothesis is that enhanced release of soluble mediators predisposes ganglia to abnormal neuron-glia crosstalk and enables development of neuro-inflammatory processes. Our work aims to delineate the biochemical pathways downstream of ATP sensing in neuronal and glial cell models, with a special emphasis on validation of new interfering methods using the last generation of drug-targeting approaches.

Selected publications

PLoS ONE 2013, 8(1):e52394.

TNFα Levels and Macrophages Expression Reflect an Inflammatory Potential of Trigeminal Ganglia in a Mouse Model of Familial Hemiplegic Migraine

Franceschini A, Vilotti S, Ferrari MD, van den Maagdenberg Arn MJM, Nistri A, Fabbretti E.

Journal of Neurochemistry 2012, 122(3), 557- 567

Functional differences between ATP-gated human and rat P2X3 receptors are caused by critical residues of C-terminal domain

Sundukova M, Vilotti S, Abbate R, Fabbretti E, Nistri A.

 
 

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